Mastermind Charlie Mascarenhas (Abhishek Bachchan) and his accomplice Riya (Bipasha Basu) are one of the greatest thieves duo in India. A friend of Charlie, Raj (Aftab Shivdasani) is killed by the Russian mafia. At Raj's funeral his wife hands over a CD to Charlie, which contains details of how Russian gold will be transferred to Romania. Charlie decides to rob the train with the help of imprisoned con-artist Victor Braganza (Vinod Khanna). They hire a team of people to join them in the robbery. The group includes Spider (Neil Nitin Mukesh) who is a best hacker in the whole world, an explosives expert Bilal Bashir (Sikander Kher), a master-disguiser Sunny (Omi Vaidya), and an illusionist Ronnie (Bobby Deol).
Charlie is also having an affair with Victor's daughter, Naina (Sonam Kapoor), who doesn't know anything about her father and Charlie's dirty business. The group hatch a plan to rob the Russian train in the sliest way possible. Spider hacks the Russian satellite system while Ronnie uses his illusion to trick the soldiers guarding the gold and the rest of the Players transfer the gold off the train. The robbery is executed successfully. However, whilst celebrating their success, it is revealed that Spider has double crossed the players, and tries to flee with the whole gold, though is stopped by Ronnie, who is then shot multiple times by Spider's assassins. The group are then chased by them, only leading to Ronnie and Riya's death. Charlie, Bilal and Sunny manage to escape when Spider bombs the place and flees with the whole gold.
Charlie calls Victor to tell him about the betrayal, but Naina hears everything. Spider's assassin breaks into the house and murder Victor. Naina decides to end contact with Charlie. For over a year, Charlie contacts Gold-dealers to find which one has the same gold as Spider stole. In New Zealand, they find a dealer who is in contact with Spider, and are able to track him down. Charlie explains to Naina that they only wanted to steal the gold so they could help achieve Victor's dream to make an big orphanage. Naina understands, and teams up with Charlie to get revenge on Spider.
In New-Zealand they find Riya, who is still alive and living there. She explains that she also wants revenge on Spider and provides them with the information of Spider's living place. Spider then flirts with Naina (unknowing her plan) and takes her to his villa. But soon enough, he gets her on gunpoint, finding out she was with Charlie as he sees a camera inside her hair. Charlie runs in to rescue her and challenges Spider that he will steal all the gold within 48 hours. Spider tries to move the gold to another country, but the Players using three large trucks and by hacking the traffic system successfully manage to take the gold before hiding it inside three Mini Coopers. Just as they are about to leave the country, they are caught by Spider, and it turns out that Riya was working with Spider the whole time.
Spider tries to force them for the gold, but when they open the Mini Cooper trunks, it turns out they are empty. Spider betrays Riya, threatening them that he would kill her. Before Charlie can give away the real hideout of the gold, Riya shoots herself. Spider then stabs Charlie, and tries to run, but is stopped by Sunny and Bilal who beat him up badly. Naina who wants revenge for the death of Victor, shoots Spider twice. It is revealed that the real Mini Coopers containing the gold are elsewhere. As the four leave the scene, Spider manages to make a final call to the Russian mafia, and tells them that Charlie has stolen Russian gold. They get the cars and leave for India, but the Mafia stops them to check the cars, and once again the Mini Coopers are empty. It is then revealed that the Mini Coopers they were driving were actually made out of the gold itself.
In the end, Bilal opens a car business. Sunny becomes a theatre actor. Charlie and Naina make Victor's dream orphanage and Charlie raises Ronnie's daughter as his own.